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FLASH GENE
Symbol PHF3 contributors: mct - updated : 06-12-2014
HGNC name PHD finger protein 3
HGNC id 8921
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal PHD domain,
  • a TFIIS domain
  • a proline-rich region
  • two bipartite nuclear localization signals
  • a central TLD domain,
  • C-terminal SPOC domain
    • HOMOLOGY
    interspecies homolog to yeast Bye1
    homolog to rattus Phf3 (79.7 pc)
    homolog to murine Phf3 (79.6 pc)
    Homologene
    FAMILY PHD finger gene family
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • PHF3 and/or PTP4A1 might play a functional role in alcohol dependence
  • once Pol II is engaged into elongation, PHF3 and DIDO1 binds directly to the transcriptional machinery, modulating its progression along the gene
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    expression significantly reduced or lost in glioblastomas, glioblastoma cell lines, anaplastic astrocytomas, and astrocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS