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FLASH GENE
Symbol ABHD5 contributors: mct/ - updated : 04-09-2018
HGNC name abhydrolase domain containing 5
HGNC id 21396
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three canonical residues of the catalytic triad with a nucleophile component including asparagine instead of serine
  • an acid motif and an histidine at residue 327
  • an alpha /beta-hydrolase domain-containing hydrolase/acyltransferase/esterase/lipase and phospholipase motifs
  • secondary structure alpha/beta hydrolase fold
    HOMOLOGY
    interspecies ortholog to C.elegans gene CGI-58
    homolog to yeast Ict1p
    intraspecies paralog to FLJ1286
    Homologene
    FAMILY
  • peptidase S33 family
  • ABHD4/ABHD5 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in cholesterol biosynthesis
  • promotes the catabolism of stored fat in adipose and non-adipose tissues, by co-activating the adipose triglyceride lipase (PNPLA2), which hydrolyzes triacylglycerol to yield diacylglycerol and fatty acid
  • acting as an acyltransferase, mediating acylation of lysophosphatidic acid
  • ABHD5, a protein activator of PNPLA2, coordinates with PLIN1 in controlling basal and stimulated lipolysis
  • DGAT1 is involved in the synthesis of triacylglycerol where as ABHD5 is a hydrolase and participates in the fatty acid oxidation process, yet inhibition of both enzymes similarly promotes prostate cancer cell death
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of ABHD5 and PLIN5 occurs mainly, if not exclusively, on the surface of lipid droplets, and is essential for regulating the activity of PNPLA2 at lipid droplets containing PLIN5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NCIE2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ABHD5, PGRMC1 and FDFT1 are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically basal cell carcinoma (BCC) with clear cell features
  • Therapy target
    ANIMAL & CELL MODELS