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FLASH GENE
Symbol HES7 contributors: mct/npt - updated : 19-02-2010
HGNC name hairy and enhancer of split 7 (Drosophila)
HGNC id 15977
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal conserved basic helix-loop-helix (bHLH) domain with lysine residues (K22, K52, and K55) that are essential not only for the instability of the protein but also for its transcriptional repressor activity (Ishii 2008)
  • one ORANGE domain
  • a C-terminal tetrapeptide (WRPW) that interacts with transcriptional co-repressors of the Groucho family (Sparrow 2008)
    • HOMOLOGY
    interspecies ortholog to murine Hes7
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in somite formation under the control of NOTCH signalling
  • regulates the periodic somite formation (Ishii 2008)
  • bHLH-Orange domain transcriptional repressor protein that is both a direct target of the Notch signaling pathway, and part of a negative feedback mechanism required to attenuate Notch signaling (Sparrow 2008)
  • involved in the developmental regulation of neurogenesis, vasculogenesis, cardiogenesis and cancer (Sparrow 2008)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text repression of transcription from the N box and E box containing promoters
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct target of the Notch signaling pathway, and part of a negative feedback mechanism required to attenuate Notch signaling (Sparrow 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCDO4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS