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FLASH GENE
Symbol DPM1 contributors: npt - updated : 09-05-2007
HGNC name dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
HGNC id 3005
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glycosyltransferase domain
  • lacking the C-terminal transmembrane domain present in the yeast homolog
  • a cAMP-dependent phosphorylation motif (Baksi 2008)
    • HOMOLOGY
    interspecies homolog to murine Dpm1
    homolog to S .cerevisiae dpm1
    Homologene
    FAMILY
  • glycosyltransferase 2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • dolichol-P-mannose synthesis from GDP-mannose and dolichol-phosphate
  • transferring mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (dol-p-man) which is the mannosyl donor in pathways leading to N-glycosylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by DPM2
    Other increased activity through protein phosphorylation is a driving force for angiogeneis (Baksi 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1E
    related resource Congenital Disorder of Glycosylation pages
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS