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FLASH GENE
Symbol NHP2 contributors: mct - updated : 19-06-2010
HGNC name NHP2 ribonucleoprotein homolog (yeast)
HGNC id 14377
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast S.cerevisiae Nhp2p
Homologene
FAMILY
  • H/ACA sno RNP nucleolar protein gene family
  • ribosomal protein L7Ae family
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
    intracellular,nucleus,nucleolus
    text dense fibrillar component of nucleole and Cajal bodies
    basic FUNCTION
  • playing a role in ribosomal RNA production and in pseudouridylation of pre rRNA's
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • telomerase complex associating with GAR1, NOP10, DKC1, TERC, TERT
  • DKC1-NOP10-NHP2 core trimer specifically recognizes H/ACA RNAs
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with TERC (assembles not one but two sets of all four of the H/ACA RNP core proteins, dyskerin, NOP10, NHP2, and GAR1)
    • cell & other
    REGULATION
    Other regulated at the transcription level depending on tissue specificity and cellular proliferative status
    ASSOCIATED DISORDERS
    corresponding disease(s) DKC6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS