| basic FUNCTION
| controlling intracellular Ca2+ levels by releasing Ca2+ from the myocardial sarcoplasmic reticulum and required for excitation-contraction coupling in cardiac muscle |
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playing a determinant role in the treshold for store-overloaded-induced calcium release and consequently for the sarcoplasmic calcium content |
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with SERCA2A (ATP2A2 variant A) is involved in vasoconstriction in pulmonary arterial smooth muscle (Clark 2010) |
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neuronal RYR2 remodeling contributes to stress-induced cognitive dysfunction  |
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RYR1, RYR2, RYR3 strongly regulate Ca2+ influx in human T cells |
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RYR1, RYR2, RYR3 are important regulators of Ca2+ signaling and Ca2+-dependent functions in human immune cells, which could be potentially used as a tool for modulating immune responses |
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RTN1 and RYR2 might act as functional partners in the regulation of cytosolic Ca(2+) dynamics the in neurons |
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in cardiomyocytes, RYR2-dependent Ca2+ release is critical for excitation-contraction coupling |
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RYR2 channels play a crucial role in the regulation of insulin secretion and glucose homeostasis |
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RYR2 plays an essential role in excitation-contraction coupling in cardiac muscle cells |
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leaky RYR2, but not ITPR2, channels cause mitochondrial Ca2+ overload and dysfunction in heart failure |
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intracellular calcium channel responsible for rapid release of Ca(2+) from the sarcoplasmic/endoplasmic reticulum (SR/ER) to the cytoplasm, which is essential for the excitation-contraction (E-C) coupling of cardiac and skeletal muscles |
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RYR2 controls mitochondrial Ca2+ dynamics and plays a specific, critical role in promoting glucose oxidation in cardiomyocytes |
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high-conductance intracellular calcium (Ca2+) channel that controls the release of Ca2+ from the sarco(endo)plasmic reticulum of a variety of cells |
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main Ca2+ release channel from sarcoplasmic reticulum in cardiomyocytes, playing a vital role in the regulation of myocardial contractile function and cardiac hypertrophy |
