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FLASH GENE
Symbol PEX12 contributors: - updated : 17-08-2007
HGNC name peroxisomal biogenesis factor 12
HGNC id 8854
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two transmembrane segments
  • a cytoplasm N terminal region required for localization to peroxisomes
  • C-terminal region contains an atypical C3HC4 RING zinc finger domain essential for peroxisome function, important for its interaction with PEX5, the import receptor for PTS1-containing proteins, as well as PEX10 and PEX19
    • HOMOLOGY
    interspecies ortholog to chimpanzee pex12
    ortholog to rattus Pex12
    ortholog to murine Pex12
    ortholog to chicken pex12
    Homologene
    FAMILY
  • peroxin 12 family
    • CATEGORY structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • involved in matrix protein import into peroxisomes
  • acting as an ubiquitin-protein ligase
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component with PEX10 of a peroxisomal membrane complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PEX5
  • PEX10
  • PEX19 via its cytoplasmic domain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PBD6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS