| basic FUNCTION
| involved in neurite extension and fasciculation |
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playing a critical early role in clustering of Na+ channels at nodes of Ranvier via interactions with receptors on Schwann cells |
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involved in axon subcellular targeting and synapse formation during neural development |
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important role for cell-cell communication in the nervous system, and regulates many different functions in the brain, suggesting that it functions as a key regulator for both developing and differentiated neural cells (Kirschbaum 2009) |
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NFASC186 optimizes communication between mature neurons by anchoring the key elements of the adult axon initial segment (AIS) complex  |
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versatile functional aspects of NFASC interactions pose it at a central position for the shaping and maintenance of neural circuitry and synaptic contacts which are implicated in nervous system disorders |
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is crucially required for the stabilization of axo-axonic synapses |
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has a unique role in node formation because it encodes glial and neuronal isoforms of neurofascin (NFASC155 and NFASC186, respectively) with key functions in assembling the nodal macromolecular complex |
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critical role of the NFASC gene in the function of myelinated axons with further redundancy in the mechanisms required for the formation of this crucial structure in the vertebrate nervous system |
