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FLASH GENE
Symbol RAD23A contributors: mct - updated : 07-04-2015
HGNC name RAD23 homolog A (S. cerevisiae)
HGNC id 9812
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a N terminal ubiquitin-like domain
  • a XPC binding domain near the C terminus
  • two ubiquitin-associated (UBA) domains: an internal UBA1 domain and a C-terminal UBA2 domain
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD23,A
    homolog to rattus Rad23a (94.21 pc)
    homolog to murine Rad23a (94.75 pc)
    Homologene
    FAMILY RAD23 family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • ubiquitin conjugating enzyme E3A, involved in the degradation of short-lived and abnormal proteins
  • have redundant roles in DNA repair
  • playing a role in DNA damage recognition in base excision repair and in postreplication repair of UV-damaged DNA
  • regulating the function of XPC by its association with the nucleotide excision repair activator TP53
  • promotes TRAF2 ubiquitin-proteasome dependent degradation
  • could be a novel regulator of antivirus immunity
  • RAD23A, which targets TRAF2 for ubiquitin-proteasome degradation, may play a role in precise control of cellular virus-triggered type I IFNs and proinflammatory cytokines production
  • CELLULAR PROCESS cell cycle
    nucleotide, repair, nucleotide excision repair
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text nucleotide excision repair (NER)
    PATHWAY
    metabolism
    signaling
    a component RAD23A-UBA (2) GFP-loop
    INTERACTION
    DNA single-stranded DNA binding
    RNA
    small molecule
    protein
  • MJD product (ataxin 3) and 26S proteasme by its UBL domain
  • MPG in excision repair pathways
  • HIV1-VPR protein
  • RAD23A, RAD23B facilitate lesion recognition by XPC but do not participate in the downstream DNA repair process
  • RAD23A down-regulated TRAF2 protein level through ubiquitin–proteasome system
  • RAD23A but not its homolog RAD23B, is a negative regulator of DDX58/IFIH1 signaling, and RAD23A was involved in DDX58/IFIH1 signaling through binding to TRAF2
  • might increase TRAF2 ubiquitination by inhibiting its deubiquitylation
  • is required for the nuclear translocation of AIFM1 during induction of cell death, and this process is energy dependent, but independent of karyopherins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS