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FLASH GENE
Symbol PGK2 contributors: mct - updated : 04-06-2020
HGNC name phosphoglycerate kinase 2
HGNC id 8898
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to PGK1,highly
Homologene
FAMILY phosphoglycerate kinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • involved in glycolysis
  • key enzyme for ATP generation
  • its expression may function solely to compensate for repressed expression of the PGK1 gene due to X-chromosome inactivation in spermatocytes
  • isozyme of the glycolytic pathway that provides ATP required for sperm motility
  • isozyme that catalyzes the first ATP-generating step in the glycolytic pathway
  • not required for the completion of spermatogenesis, but is essential for sperm motility and male fertility
  • is required for normal sperm motility and fertility in mammals
  • PGK1 and PGK2 are involved in spermatogenesis and thought to be related to sperm motility
  • GAPDHS and PGK2, two isozymes restricted to the male germline, catalyze successive steps in the glycolytic pathway in mammalian sperm
  • expression levels of GAPDHS, PGK2 and LDHC in the spermatozoa were closely correlated with progressive sperm motility
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTBP2 (potential trans-acting factor that helps to stabilize PGK2 mRNA in male germ cells)
  • binding of PBX4, plus its coactivator PREP1, is a rate-limiting step leading to the initiation of tissue-specific transcription of the PGK2 gene
  • KHSRP serves as a decay-promoting factor for PGK2 mRNA in male germ cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    activation with others testis specific retrogenes in the ovary and ovarian cancers
    constitutional     --low  
    decreased in the testis with ageing
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a promising molecular candidate for the assessment of sperm quality and the screening of male contraceptive targets
    • Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    promising molecular candidate for the screening of male contraceptive targets
    ANIMAL & CELL MODELS