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FLASH GENE
Symbol SLC9A5 contributors: mct/npt - updated : 19-02-2018
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), member 5
HGNC id 11078
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten (? twelve) transmembrane segments (TM)
  • with a large acidic cytoplasmic C terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • solute carrier protein family 9
  • monovalent cation:proton antiporter 1 (CPA1) transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • brain-enriched Na(+)/H(+) exchanger that dynamically shuttles between the plasma membrane and recycling endosomes (Diering (2009)
  • not only resides in the plasma membrane but also accumulates in recycling vesicles by means of clathrin-mediated endocytosis (Szabo 2005)
  • basic FUNCTION
  • involved in intracellular pH regulation and cell volume
  • playing an important role in signal transduction
  • may play important roles in ion homeostasis and cell-volume regulation (Onishi 2007)
  • brain-enriched Na(+)/H(+) exchanger, serving as a mechanism that acutely controls the local pH environment (Diering 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binds to the N- and C-terminal cytosolic extensions of SCAMP2 (Diering 2009)
  • cell & other
    REGULATION
    Other dynamically regulated by phosphatidylinositol 3-kinase and by the state of F-actin assembly
    regulated by GNB2L1 (Onishi 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS