protein
| binding to to BMP6 and BMP7 |
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binding to RUNX2 by its proximal promoter (contributing to its differential expression in two osteosarcoma cell lines) |
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ligand for LRP5/LRP6 and a WNT signaling inhibitor |
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interacting with POSTN (mechanical loading increases POSTN expression, which is necessary to inhibit SOST expression and thereby to up-regulate osteoblast functions) |
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physical association of SP7 with SOST promoter |
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interaction between sclerostin and the C-terminal portion of the receptor tyrosine-protein kinase ERBB3, modulating the activity of this receptor in osteoblasts |
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LRP4 is a sclerostin (SOST) interaction partner (interaction of sclerostin with LRP4 is required to mediate the inhibitory function of sclerostin on bone formation, thus identifying a novel role for LRP4 in bone) |
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its expression is modulated by PTH through a MEF2 responsive element, present in the distal ECR5 SOST enhancer |
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interacting with ACVR1 (ACVR1 negatively regulates bone mass by suppressing Wnt signaling through SOST and DKK1) |
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MEF2C is the main transcription factor responsible for bone enhancer ECR5-dependent SOST transcriptional activation in the adult skeleton |
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complex role of POSTN on bone anabolism, through the regulation of SOST, Wnt-CTNNB1 signaling, and osteoblast differentiation |
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POSTN could be involved in the regulation of SOST expression and bone anabolism in response to PTH |
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BMP2 decreases periosteal cell proliferation and induces apoptosis via the activation of Wnt inhibitors DKK1 and SOST |
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regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2 |
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SOST and its paralog SOSTDC1 coordinate digit number in a GLI3-dependent manner |
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SERPINF1 may regulate SOST expression by osteocytes leading to enhanced osteoblastic differentiation and increased matrix mineralization |