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FLASH GENE

Symbol

NOL3

contributors: mct - updated : 29/10/2008

HGNC name	nucleolar protein 3 (apoptosis repressor with CARD domain)
HGNC id	7869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N terminal caspase recruitment domain (CARD)
	a C terminal region rich in proline and glutamic acid

mono polymer

polymer

HOMOLOGY

interspecies	homolog to rattus Nol3 (85.4 pc)
	homolog to murine Nol3 (85.1 pc)

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	involved in alternative splice site selection
	inhibiting caspase 2 and 8
	being a Ca(2+)-dependent regulator of caspase 8 and cell death
	inhibitor of apoptosis in that it antagonizes both the extrinsic (death receptor) and intrinsic (mitochondrial/ER) apoptosis pathways

CELLULAR PROCESS	cell life, antiapoptosis
	nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

text	regulation of apoptosis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule	metal binding,
	Ca2+

protein	alternating apoptosis induced by TRADD, FADD
	binding to the RS domain of SFRS9 (Srp30c)
	interacting with TFPT

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in the epithelium of primary breast cancers compared with benign breast tissue and to confer chemo- and radiation-resistance tumoral     --over   in most colon cancer cell lines and in almost all primary colon cancers compared with corresponding controls

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	marker of human colon cancer
Therapy target

ANIMAL & CELL MODELS