| basic FUNCTION
| potential contributor with NPC1 in transport of cholesterol out the lysosome |
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relevant to cholesterol transport and secretory protein from human epididymis  |
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soluble lysosomal glycoprotein that binds cholesterol, an have specialized function in lysosomal sterol transport |
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intralysosomal protein that binds cholesterol |
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plays an important role in endo/lysosomal cholesterol trafficking by markedly accelerating the rates of cholesterol transport |
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might regulate sodium reabsorption in the terminal nephron by interacting with SCNN1A system |
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participates in SCNN1A ubiquitination by binding with the NEDD4L C2 domain |
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required for efficient membrane fission events from nascent hybrid organelles, which is thought to be required for the reformation of lysosomes and the release of lysosomal cargo-containing membrane vesicles |
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with NPC1 can function independently of one another in the egress of certain membrane-impermeable lysosomal cargo |
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role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion |
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soluble NPC2 and membrane-bound NPC1 are cholesterol-binding lysosomal proteins required for export of lipoprotein-derived cholesterol from lysosomes |
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action for NPC1 and NPC2 in mediating cholesterol efflux |
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by negatively regulating ERK 1/2 MAPK phosphorylation may efficiently suppress development of maladaptive tissue remodeling and inflammation |
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positive regulator of biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport |
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function of NPC1, NPC2 within lysosomes are linked closely |
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thought to play an important role in extracting cholesterol from intralysosomal membranes that are rich in cholesterol and bis(monoacylglycerol) phosphate |
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importance of the interaction between NPC1 and NPC2 proteins to accomplish cholesterol delivery from lysosomes into the cytoplasm |
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NPC2 delivers cholesterol to the perimeter membrane of late endosomes, where it becomes available for transport to mitochondria without requiring NPC1 |
