basic FUNCTION
| cytoplasmic adaptor protein |
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cytoplasmic phosphoproteins that play a role in vesicle formation and transport |
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in addition to a crucial role in endocytic internalization, complexes with EHDs play an important role in endocytic receptor recycling |
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participate in cellular membrane trafficking, in regulation of dynamin-mediated endocytotic processes and have been shown to generate membrane tubules |
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may control other proteins during development |
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may regulate gastrulation by controlling the population of activated alpha5beta1 integrin and cytoskeleton strength during cell movement |
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function in dynamic microtubuli nucleation |
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intracellular adapter protein involved in vesicle transport, membrane dynamics and actin reorganisation |
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novel function for PACSIN1, PACSIN2, PACSIN3 in dynamic microtubuli nucleation |
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regulates cell spreading and migration, which are dependent on CCND1 expression |
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mediates membrane sculpting by caveolin-1 in caveola morphology and recruits dynamin-2 for caveola fission |
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PACSIN2 acts as negative regulator of EGF receptor signaling |
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is a key regulator of growth factor signaling in epithelial and in endothelial cells, regulating growth factor receptor surface levels and downstream signaling |
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PACSIN2 contributes to kidney development and repair in a nephron-specific manner |
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F-BAR domain protein, able to associate with actin filaments using the same concave surface employed to bind to membranes, while some other tested N-BAR and F-BAR proteins (endophilin, CIP4 and FCHO2) do not associate with actin |
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PACSIN2 at caveolae stabilizes caveolae, but its removal by phosphorylation could induce both caveolar endocytosis and flattening. |
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new role for the F-BAR protein PACSIN2 in the control of CDH5-based endothelial adhesion |
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through its role in promoting apical endocytosis, PACSIN2 plays a role in controlling microvillar morphology |