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FLASH GENE

Symbol

CD7

contributors: mct - updated : 11-03-2010

HGNC name	CD7 molecule
HGNC id	1695

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic NK cell Blood/Hematopoietic thymocyte Lymphoid/Immune B cell Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an immunoglobulin-like domain

conjugated

GlycoP , LipoP

HOMOLOGY

interspecies	ortholog to murine Cd7
	homolog to C.elegans C14F5.2

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

immunity/defense , antigen , receptor membrane tyrosine kinase

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION	playing an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development
	may act as an Fc receptor for IgM in lung microvascular endothelial cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	calcium ion transport

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to SECTM1 (K12)
	binding to PI3k and to PI4K

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         marker of T cell acute lymphocyte leukemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	CD7 epxression in CD4+ T cells discriminates between Hodgkin lymphoma (overexpressed) and reactive lymphadenopathy
Therapy target
	System Type Disorder Pubmed cancer hemopathy   loss of CD7 implies a worse prognosis in adult T-cell leukemia/lymphoma

ANIMAL & CELL MODELS