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FLASH GENE
Symbol MAP6 contributors: mct - updated : 28-01-2015
HGNC name microtubule-associated protein 6
HGNC id 6868
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemuterus   
 male systemprostate   
 male systemtestis   
Respiratorylung    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five tandem repeats of 46 amino acids
  • a putative SH3-binding motif near its N terminus
  • calmodulin binding motif
  • HOMOLOGY
    Homologene
    FAMILY
  • STOP family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • the distribution is uniform between the cytoplasm and neurites of neurons
  • colocalizes with neurofilament-rich inclusions in spinal chrod and brain neurons of patients with amyotrophic lateral sclerosis (Letournel 2003)
  • basic FUNCTION
  • acting on the stability and dynamics of microtubules
  • playing an important role for synaptic plasticity
  • microtubule-associated protein stabilizing microtubules in a calmodulin (CaM)-dependent manner
  • is significantly enriched for known tumor suppressors and likely contains many novel tumor suppressors
  • MAP6, MAP6D1 having multimerization activity, which may be relevant to neuronal differentiation and synaptic functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to microtubules and calmodulin for calmodulin regulation of microtubule dynamics or stability, specifically during mitosis where CaM and MAP6 colocalize
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Map6 deletion in mice severely alters integrated brain functions and is associated with synaptic defects, suggesting that MAP6s may also have alternative cellular roles