| basic FUNCTION
| proton gated cation channel subunit modulatory subunit of ACCN1 (ASIC2A) |
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involved in modulating moderate- to high-intensity pain sensation |
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may play an important role in the detection of lasting pH changes |
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might play a role in the neuronal response to noxious acidosis in sensory and central pathways |
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ligand-gated cation channel activated by extracellular protons, and is associated with an exercise-induced pressor reflex and possibly autonomic imbalance |
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ASIC3-containing neurons have a wide variety of sensory modalities in the vagal and glossopharyngeal sensory ganglia  |
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may be involved in blood pressure regulation |
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thus, peripherally located ASIC1 and ASIC3 play different roles in the development of hyperalgesia after muscle inflammation |
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contribution of ASIC3 to established hypersensitivity associated with inflammation suggests that this channel may be an effective analgesic target for inflammatory pain states |
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particularly important sensor of nonadaptive pain associated with tissue acidosis |
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ASIC3A, ASIC3B, or ASIC3C are able to directly sense extracellular pH changes not only during acidification (up to pH 5.0), but also during alkalization (up to pH 8.0) |
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can thus constitute a particularly efficient molecular sensor for alkalization and/or recovery from acidification in neurons and other cell types where it may be expressed |
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is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers |
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important role of ASIC3 channels in regulating inflammatory pain via coincident detection of extracellular protons and inflammatory mediators |
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important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli |
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activation of ASIC3 and TRPV1 as well as enhanced SCN10A activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain |
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fatigue reduces pH in muscle that subsequently activates ASIC3 on macrophages to enhance hyperalgesia to muscle insult |
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involved in many aspects of nociception, both in peripheral and central neurons |
