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FLASH GENE
Symbol GPR50 contributors: mct/npt - updated : 05-05-2010
HGNC name G protein-coupled receptor 50
HGNC id 4506
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus  
 brainmidbraintectum highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor, lacking N-linked glycosylation sites
  • a large C terminus tail
    • HOMOLOGY
    intraspecies homolog to melatonin-related receptor
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • melatonin-related receptor potentially involved in neuroendocrine function
  • playing a role in the regulation of lipid metabolism
  • involvement in mental disorders with links to several disease mechanisms (Grünewald 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • heterodimerizes constitutively and specifically with MT(1) and MT(2) melatonin receptors, and specifically inhibits MT1 melatonin receptor function through heterodimerization
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • neurite outgrowth inhibitor RTN4 is an interacting partner of GPR50
  • role for GPR50 in NR3C1 signalling through interaction with kat5
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased neurite length and filopodia- and lamellipodia-like structures in differentiated Neuroscreen-1 cells (Grünewald 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS