basic FUNCTION
| playing a role in regulating the functional activity of URAT1-mediated urate transport in the apical membrane of renal proximal tubules |
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plays a specific role in stabilizing Muc3 in the apical membrane of small intestinal enterocytes |
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major scaffolder in brush borders of proximal tubular cells |
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multi-PDZ domain-containing adaptor protein that binds to the C terminus of the high density lipoprotein receptor, scavenger receptor, class B, type I (SCARB1), and controls the posttranscriptional, tissue-specific expression of this lipoprotein receptor |
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required for HDL activation of endothelial nitric oxide synthase and cell migration (Zhu 2008) |
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uniquely required for HDL/SCARB1 signaling in endothelium, and through these mechanisms, it is critically involved in the maintenance of endothelial monolayer integrity (Zhu 2008) |
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member of the family of proteins that is instrumental in preventing cardiovascular disease by maintaining normal lipoprotein metabolism |
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NHERF1, NHERF2, and PDZK1, modulate CFTR membrane retention, conductivity, and interactions with other transporters |
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reconstitutes calcium inhibition of SLC9A3 activity by anchoring SLC9A3 basally and releasing it with elevated Ca(2+) |
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by entering into the ternary complex, PDZK1 can both enhance the scaffolding at the apical membrane as well as augment SLC9A3R1 role in microvilli formation |
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indirect involvement of PDZK1 in HCV (hepatitis C virus) entry via its ability to interact with SCARB1 and enhance its activity as an HCV entry factor |
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plays a role in the stabilization/retention of SLC34A3 in the microvilli more than in the trafficking of the transporter to the apical membrane |
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plays an important role in the adaptation of SLC34A3 to low Pi conditions |