| SUBCELLULAR LOCALIZATION
| extracellular
|
| intracellular
|
|
| intracellular,cytoplasm,organelle,membrane
|
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
|
| intracellular,cytoplasm,organelle,Golgi
|
|
| intracellular,cytoplasm,cytosolic,vesicle
|
|
| intracellular,nucleus
|
| text
| extracellular matrix |
|
in the cis-Golgi compartment |
|
co-localizes with POMGNT1 in the Golgi apparatus |
| basic FUNCTION
| regulation of neuronal migration in the fetal cerebrum and cerebellum |
|
involved in migration and assembly of neurons during cortical histogenesis,not of basement membrane formation |
|
required for the maintenance of muscle integrity, cortical histogenesis and normal ocular development |
|
may be involved at different steps in O-mannosylglycan synthesis of alpha-dystroglycan |
|
might play a significant role in post-translational modification of synaptic proteins in neuronal cells |
|
is involved in basement membrane formation via the glycosylation of alpha-dystroglycan (alpha-DG), and hypoglycosylation of alpha-DG provokes the muscular, CNS and eye lesions of FCMD  |
|
is a very low abundance protein, required for glycosylation of alpha-dystroglycan at the Golgi, though not substantially-glycosylated itself |
