protein
| binding to TERC |
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association with PINX1 within nucleoli might be through an indirect interaction and is mediated by a novel domain within the central region of PINX (interaction between PINX1 and TERT within the nucleolus might constitute a rapid responsive mechanism on telomerase functional modulation, important for cellular homeostasis) |
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interacting with SMYD3 (direct target of SMYD3 contributing to a SMYD3-mediated cellular transformation)![](pubmed.jpg) |
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binding to SMAD3 ![](pubmed.jpg) |
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interacting with SMARCA4 and activating Wnt/beta catenin signalling pathway ![](pubmed.jpg) |
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one of the major targets of KLF4 in cancer and stem cells to maintain long-term proliferation potential ![](pubmed.jpg) |
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interacting with a putative gene on human chromosome 5 contributes to its transcriptional silencing ![](pubmed.jpg) |
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RUVBL2 is a transcriptional regulator of TERT ![](pubmed.jpg) |
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FEN1 and telomerase association occurs throughout the S phase, with the maximum association in the mid S phase ( |
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![](pubmed.jpg) |
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DKC1 promotes TERT stability, endorsing the development of TERT supplementation strategies for the treatment of DKC1 ![](pubmed.jpg) |
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NVL2 associates with catalytically competent telomerase through an interaction with TERT, and this association could be specific ![](pubmed.jpg) |
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TCF4 may bind to TERT promoter and activate TERT gene transcription upon forming a transcriptional complex with CTNNB1 ![](pubmed.jpg) |
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during the cell cycle, DYRK2 interacts with TERT at the G2/M phase and induces degradation ![](pubmed.jpg) |
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DYRK2-associated DDB1-UBR5-VPRBP E3 ligase inhibits telomerase by TERT degradation ![](pubmed.jpg) |
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is a direct target of the HH signaling pathway, and HH signaling regulates telomerase reverse transcriptase in cancer cells ![](pubmed.jpg) |
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MCRS1 is a negative regulator of TERT expression and telomerase activity ![](pubmed.jpg) |
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DEK emerges as an TERT repressor shared by various leukemia subtypes and seems involved in the deregulation of numerous genes associated with leukemogenesis ![](pubmed.jpg) |
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PINX1 may maintain telomere integrity by regulating TERF1 stability and TERT may act as both a positive and a negative regulator of TERF1 homeostasis in a PINX1-dependent manner ![](pubmed.jpg) |
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CPSF4 plays a critical role in the regulation of TERT expression and lung tumorigenesis and may be a new prognosis factor in lung adenocarcinomas ![](pubmed.jpg) |
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interaction between TERT and PTTG1 by association of XRCC6 might be important for the enhancement of the limited self-renewal activity of MSCs and for understanding the regulatory mechanisms of self-renewal ![](pubmed.jpg) |
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FOXO3 functions downstream of SIRT1 and prevents the induction of cellular senescence by enhancing TERT gene expression ![](pubmed.jpg) |
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MYC functioned in maintaining chromatin-dependent repression of the TERT gene in addition to activating its promoter ![](pubmed.jpg) |
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stability of PINX1 is maintained in nucleolus in the presence of TERT, suggesting a role of TERT in the regulation of PINX1 steady-state levels ![](pubmed.jpg) |
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PTBP1 interacts with TERT pre-mRNA in a NOVA1 dependent fashion ![](pubmed.jpg) |
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CPSF4 facilitated colorectal tumorigenesis and development partially through transcriptionally regulating TERT expression by cooperating with NFKB1 and co-anchoring at TERT promoter -321 to -234 fragment ![](pubmed.jpg) |
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RBM10 regulates human TERT gene splicing and inhibits pancreatic cancer progression ![](pubmed.jpg) |
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NKX2.4 regulates TERT and CLPTM1L expression ![](pubmed.jpg) |
Variant & Polymorphism
SNP
| significant association of an SNP in intron 2 of the TERT gene (rs2736100), which encodes a reverse transcriptase that is a component of a telomerase, to idiopathic pulmonary fibrosis ![](pubmed.jpg) |
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variants in TERT can impede telomere elongation causing stem cells to enter premature replicative senescence and/or apoptosis as telomeres become critically short ![](pubmed.jpg) |
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SNPs of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T), may be associated with a reduced risk of squamous cell carcinoma of the head and neck, particularly for their combined effect ![](pubmed.jpg) |
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rs2736100 associated with risk of lung adenocarcinoma ![](pubmed.jpg) |
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association between genetic marker rs2735940 and TGCT risk ![](pubmed.jpg) |
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variants associated with increased risk of haematological malignancies, including myelodysplastic syndrome and acute myeloid leukaemia as well as chronic lymphocytic leukaemia ![](pubmed.jpg) |
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two non-synonymous substitutions in the catalytic domain of the telomerase reverse transcriptase gene TERT: V791I and V867M increasing the risk of age-related disease idiopathic pulmonary fibrosis with telomere shortening ![](pubmed.jpg) |
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in UM rs452384 is a functional variant that mediates allele-specific binding of the NKX2.4 nuclear factor and the transcriptional activity of the region, including TERT and CLPTM1L ![](pubmed.jpg) |
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exposure to polycyclic aromatic hydrocarbons (PAHs) can accelerate the TL shortening and this effect can be modified by TERT-CLPTM1L variants ![](pubmed.jpg) |
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