basic FUNCTION
| 19/22S regulator of proteasome, non ATPase subunit p27 |
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acting as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins |
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implicated in diabetes onset and in degradation of intracellular proteins in antigenic peptides in the immune response to antigen presentation by MHC class I cells |
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possible role of PSMD9 in microvascular pathology may be related to a causative pathogenetic role in inflammation as part of an autoimmune process |
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is a PDZ domain containing chaperone of proteasome assembly |
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potential role of PSMD9 in transcriptional regulation, mRNA processing and editing, hormone and receptor activity and protein translation |
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PSMD9 plays a role in trafficking of ribosomal proteins into the nucleolus, therefore contributing to the maintenance of structural and morphological organization of the membrane-less nucleolar compartment |