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FLASH GENE
Symbol PJA2 contributors: mct - updated : 18-01-2013
HGNC name praja 2, RING-H2 motif containing
HGNC id 17481
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
RING-H2 zinc finger domain
HOMOLOGY
interspecies homolog to rabbit neuro DAP1
intraspecies homolog to PJA1
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
text
  • postsynaptic density of axosomatic synapse
  • cytoplasmic side of the membrane
  • basic FUNCTION
  • control of post-synaptic density (PSD) for maintaining the function of neurons
  • RING ligase that controls the stability of PRKACA regulatory (R) subunits
  • required for efficient nuclear cAMP signalling and for PRKACA-mediated long-term memory
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • formation and maintenance of PSD
  • synaptic
  • protein sorting machining
  • PATHWAY
    metabolism
    signaling neurotransmission
    synaptic communication and plasticity
    a component
  • SIK2-CDK5R1-PJA2 complex is essential for glucose homeostasis and provides a link between CDK5R1-CDK5 and the AMPK family in excitable cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SPTBN1 in a TGF-beta-dependent manner, with a fivefold increase of PJA1 and PJA2 expression and a subsequent decrease in SPTBN1 and SMAD4 expression, in gastrointestinal cancer cell lines
  • forms a stable complex with, and is phosphorylated by, PRKACA
  • cell & other
    REGULATION
    Phosphorylated by PRKACA
    Other downregulated by exonotomy
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS