| protein
| microtubule-associated protein RP/EB family member 1, MAPRE1 ( |
|
alpha-catenin, beta-catenin, and plakoglobin ( |
|
junction plakoglobin, JUP ( |
|
glycogen synthase kinase 3 beta, GSK3beta |
|
neuronal and endocrine dig,NE-dlg ( |
|
DAP-1 ( |
|
CDC20 and MAD2 ( |
|
protein phosphatase 2A (PP2A) regulatory subunit, B56 ( |
|
RP1 ( |
|
Rac-specific guanine nucleotide exchange factor GEF |
|
protein tyrosine phosphatase PTP-BL |
|
budding uninhibited by benzimidazoles 1, BUB1 and budding uninhibited by benzimidazoles 3, BUB3 during mitosis |
|
rotein phosphatase 2 regulatory subunit B' alpha, PPP2R5A |
|
seven in absentia homolog 1, SIAH1 ( |
|
kinesin superfamily (KIF) 3A-KIF3B proteins, microtubule plus-end-directed motor proteins and the kinesin superfamily-associated protein 3 (KAP3) |
|
nuclear export factor chromosome maintenance region 1, Crm-1 |
|
casein kinase 2, CK2 |
|
dynactin |
|
mucin 1 cell surface associated, MUC1 |
|
transcription factor AP-2 alpha, TFAP2A ( |
|
C-terminal binding protein, CtBP |
|
IQ motif containing GTPase activating protein 1, IQGAP1 |
|
budding uninhibited by benzimidazoles 1 homolog beta, BUB1B |
|
14-3-3 sigma |
|
TRAF-binding protein domain, TRABID |
|
ARHGEF4 and SPATA13 |
|
APC interacts with RANBP2, a microtubule-binding nucleoporin |
|
CCNA2/CDK2 specifically associates with APC in late G2 phase and phosphorylates it at Ser-1360, located in the mutation cluster region of APC |
|
bound to DVL1 directly and this complex played a role in the WNT5A-dependent formation of cell-substrate adhesions and polarized cell migration |
|
Axin ( |
|
SMAD7 and MAPK14 mitogen-activated protein kinase together regulate the expression of APC and cell migration in prostate cancer cells in response to TGFB1 stimulation |
|
involved in protein modification, ubiquitin cycle |
|
HECTD1 promotes the APC-AXIN1 interaction to negatively regulate WNT signaling |
|
in cancer cells, NRIP1 stimulated APC transcription and inhibited CTNNB1 activation and target gene expression |
|
APC interactions with the mitochondrial kinesin-motor complex RHOT1/TRAK2 that were mediated by the APC C-terminus |
|
likely functions as a tumor suppressor in breast cancer that is mediated by repressing WNT/CTNNB1 signaling pathway via upregulation of APC expression |
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
| somatic mutation
|
|
|
| |
in prostate carcinoma | | tumoral
|
| LOH
|
|
| |
in pancreatoblastoma | | tumoral
|
|
|
| loss of function
| |
in colon, thyroid, stomach, intestine cancer, hepatocellular carcinoma, in progression | | constitutional
|
|
| --low
|
| |
in lung carcinoma | | tumoral
|
|
| --other
|
| |
loss of APC through aberrant methylation is associated with the aggressive behavior of both sporadic and familial breast cancer | | constitutional
|
|
|
| loss of function
| |
tissue-dependent consequences of APC inactivation on proliferation and differentiation of ciliated cell progenitors by coordinating WNT and NOTCH1 signaling | |
|
| Mice with Apc nonsense mutation have multiple intestinal neoplasia | |
mice with homozygous truncated mutation in Apc gene die in utero before day 8 of gestation. Heterozygous mice develop multiple polyps mostly in the small intestine |
|
chain-termination mutation in exon 15 of the mouse Apc gene leads to development of intestinal tumors |
|
predisposes to mammary carcinomas and focal alveolar hyperplasias in mice harboring Apc gene point mutation |
|
Dpc4 mutation into the Apc(delta716) knockout mice lead to development of intestinal polyps and more malignant tumors |
|
treatment of Apc delta716 mice with a novel COX-2 inhibitor reduced the polyp number suggesting that COX-2 can a therapeutic agent for colorectal polyposis and cancer |
|
cells carrying a truncated APC gene (Min) are defective in chromosome segregation |
|
COX-2 inhibits intestinal polyps in Apc(Delta716) mice and may be useful as chemopreventive and therapeutic agents in humans at risk for colorectal neoplasia |
|
mouse embryonic stem cells homozygous for multiple intestinal neoplasia or Apc1638T alleles display extensive chromosome and spindle aberrations |
|
Apc+/Delta716 Cdx2+/- compound mutant mice develop six times more adenomatous polyps |
|
zebrafish with truncation of apc gene have excessive endocardial cushions |
|
BubR1(+/-)Apc(Min)(/+) compound mutant mice develop ten times more colonic tumors |
|
Apc-deficient zebrafish display developmental abnormalities of both the lens and retina |
|
rat carrying a knockout allele in apc gene develops multiple neoplasms with a distribution between the colon and small intestine |
|
simultaneous deletion of both Apc and Myc in the adult murine small intestine rescued the phenotypes of perturbed differentiation, migration, proliferation and apoptosis, which occur on deletion of Apc |
|
hematopoietic system of mice with the Apc(min) allele showed no abnormality in steady state hematopoiesis, bone marrow from Apc(min) mice showed enhanced repopulation potential but was unable to repopulate secondary recipients because of loss of the quiescent HSC population |
