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FLASH GENE
Symbol CA2 contributors: mct - updated : 13-04-2018
HGNC name carbonic anhydrase II
HGNC id 1373
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 stomach   highly
Nervousplexus choroid    
Reproductivefemale systemovary  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoligodendrocyte
Skeletonosteoclast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
HOMOLOGY
interspecies homolog to murine Car2 (80.8pc)
homolog to rattus Car2 (80.8pc)
Homologene
FAMILY
  • alpha carbonic anhydrase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • reversibly hydrating CO2 in cellular ion transport and homeostasis
  • required for the Ca2+-regulated exocytosis of secretory vesicles
  • essential for bone resorption and osteoclast differentiation
  • regulating SLC9A1 activity via a phosphorylation-regulated CAII binding site in SLC9A1 tail
  • may be involved in the development of brain
  • rotative stress has a significant effect on CA2, FAS, FASLG, OSCAR, and TRAP gene expression in osteoclasts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Zn2+
  • protein
  • interacting with SLC4A4 a,d thus regulating its transporter activity
  • CA2 interacts at high affinity with the C-terminal (Ct) domains of SLC4A8, but can bind to GST-SLC4-Ct fusion proteins only when the CA2 is immobilized and the fusion protein is soluble, and not vice versa
  • both LDB1 and CTCF are required for enhancer-CA2 looping, and the domain of LDB1 contacted by CTCF is necessary to rescue CA2 transcription in LDB1-deficient cells
  • cell & other
    REGULATION
    induced by during chondrogenesis
    inhibited by zonisamides
    sulfonamides incorporating thioureido-sulfanilyl scaffolds
    Other regulated by extracellular signal-regulated protein kinase, protein kinase C, and p38 kinase, signaling molecules known to regulate chondrogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s) CA2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in osteoclast-like cells in advanced atherosclerotic plaques
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS