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FLASH GENE
Symbol ICA1 contributors: mct - updated : 07-03-2015
HGNC name islet cell autoantigen 1, 69kDa
HGNC id 5343
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart   highly
Endocrinepancreas   highly
 thyroid    
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal half contains a BAR domain, a module that can bind/bend membranes and interacts with phospholipids
  • HOMOLOGY
    interspecies homolog to murine Ica1
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • enriched in the Golgi complex
  • basic FUNCTION
  • autoantigen associated with insulin-dependent diabetes mellitus
  • is a novel RAB2A effector having a role in regulating the early transport of insulin secretory granule proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB2A binds to ICA1 in a GTP-dependent fashion and recruits it to membranes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate autoimmune target in insulin dependent diabetes
    Marker
    Therapy target
    ANIMAL & CELL MODELS