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FLASH GENE
Symbol GNB2 contributors: mct - updated : 08-04-2016
HGNC name guanine nucleotide binding protein (G protein), beta polypeptide 2
HGNC id 4398
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposebrown   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a N terminal alpha-helical segment followed by seven WD (Trp-Asp) repeats, forming a propeller structure
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nuclear envelope
basic FUNCTION
  • playing a role in the release of ATP from human erythrocytes
  • in stellate ganglion neurons, GNB2 and GNB4 normally maintain the coupling of Ca(2+) channels with the receptors, with the latter subtype responsible for maintaining the integrity of both pathways
  • is required for starvation-induced NFKB1 activation and constitutive NFKB1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATXN10 (coexpression of ataxin 10 and GNB2 potently activated the Ras-MAP kinase-Elk-1 cascade, a mechanism for inducing neuritogenesis)
  • KCNJ6 is capable of interacting with GNB1, GNB2, GNB3 and not GNB4 or GNB5
  • GNGT1, GNG2, GNB1, GNB2, GNB3, interacts with MTOR and promotes its activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    GNB1 and GNB2 alterations confer transformed and resistance phenotypes across a range of human tumors and may be targetable with inhibitors of G protein signaling
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS