Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDK7 contributors: mct - updated : 18-05-2013
HGNC name cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
HGNC id 1778
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
cell lineage
cell lines breast cancer lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to Xenopus p40-M015
homolog to murine Cdk7
ortholog to yeast S.cerevisiae cdc28
Homologene
FAMILY
  • cyclin-dependent kinase family
  • ser/thr family of protein kinases
  • CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • CDK-activating kinase 1, linking transcription and the cell-cyle machinery
  • functions as a master cell cycle regulator by phosphorylating cyclin-dependent kinases for cell cycle progression
  • having a putative role in oxidative stress
  • submodule of TFIIH acting as a physiological roadblock to adipogenesis by inhibiting PPARgamma activity
  • ELL and CDK7 play essential yet distinct roles during transcription-coupled repair (TCR)
  • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
    nucleotide, repair
    nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
    a component
  • component of the multisubunit complex TFIIH (GTF2H)
  • component of an aternary complex with CCNH and MNAT1 (see symbols)
  • trimeric CDK7/cyclin H/MNAT1 complex functions in cell cycle regulation, as the Cdk-activating kinase, and in transcription, as a module of the general transcription factor TFIIH )
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating POLR2A, when complexed and associated with GTF2H
  • phosphorylating CDK2 and CDC2
  • PRKCI associates with CDK7
  • CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation
  • cell & other
    REGULATION
    inhibited by inactivated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to breast cancer
    Variant & Polymorphism other
  • CDK7 TT genotype had increased risk of breast cancer (
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS