Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PCMT1

contributors: - updated : 08-03-2006

HGNC name	protein-L-isoaspartate (D-aspartate) O-methyltransferase
HGNC id	8728

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive mouth tongue     highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

interspecies	ortholog to murine Pcmt1
	ortholog to rattus pcmt1

Homologene

FAMILY

l-isoaspartyl/d-aspartyl protein methyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION	protein repair enzyme initiating the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form
	playing a role in the repair and/or degradation of damaged proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to neural tube defect

Variant & Polymorphism other	polymorphism (Ile120Val)associated with an increased risk of folate-responsive neural tube defect (genetic modifier for the risk of spina bifida)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS