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FLASH GENE
Symbol MRGPRD contributors: mct - updated : 07-12-2011
HGNC name MAS-related GPR, member D
HGNC id 29626
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cordsensory ganglia    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to rattus Mrgprd
ortholog to murine Mrgprd
intraspecies homolog to MAS1
Homologene
FAMILY
  • G-protein coupled receptor 1 family
  • Mas subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral membrane protein
  • localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine
  • sensory neurons expressing the MRGPRD receptor are known to innervate the outermost living layer of the epidermis, the stratum granulosum
  • basic FUNCTION
  • may regulate nociceptor function and/or development, including the sensation or modulation of pain
  • functioning as a specific membrane receptor for beta-alanine
  • acting as a rhodopsin-like receptor
  • marks a distinct subset of sensory neurons that transmit polymodal nociceptive information from the skin epidermis to the substantia gelatinosa (SG, lamina II) of the spinal cord
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between MRGPRD and KCNQ2 that contributes to an increase in excitability of dorsal root ganglion neurons and thus may enhance the signaling of primary afferent nociceptive neurons
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS