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FLASH GENE
Symbol CLEC4G contributors: mct - updated : 29-06-2017
HGNC name C-type lectin superfamily 4, member G
HGNC id 24591
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiens
Lymphoid/Immunelymph node     Homo sapiens
 thymus     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte Homo sapiens
Digestiveepithelial cell Homo sapiens
Lymphoid/Immunedendritic cell Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • type II antifreeze protein signature
  • a single C-type lectin-like domain at the COOH terminus
  • HOMOLOGY
    interspecies homolog to murine Clec4g
    Homologene
    FAMILY C-type lectin DC-SIGN family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type II integral to membrane
  • basic FUNCTION
  • acting as a lectin receptor
  • pathogen-associated molecular pattern receptor in human myeloid cells
  • likely participates in antigen uptake and internalization, and might be a suitable target molecule in vaccination strategies
  • acts as a pathogen attachment factor for Ebolavirus and the SARS coronavirus, and its expression can be induced by interleukin-4 on monocytes and macrophages
  • specifically recognized activated T cells and negatively regulated their immune responses
  • negatively regulates hepatic T-cell immune response
  • not only acts as an attachment factor for pathogens, but also recognizes "endogenous" activated T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • sugar
  • protein
  • CD44 is the first identified endogenous ligand of CLEC4G, and similarly, that CLEC4G is a novel ligand of CD44
  • CLEC4G-mediated signaling up-regulates the threshold of CD4(+) T cell activation via tuning the expression of CBLB
  • novel role of CLEC4G in negatively regulating BACE1 function
  • DPP4, AGTR2, SLC4A1, KREMEN1, ASGR1, NPR1, TMEM30A, CLEC4G, and LDLRAD3, along with ACE2 facilitate SARS-CoV-2. virus entry and transmission
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    may be a promising new target for intervention in metastasis formation
    ANIMAL & CELL MODELS