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FLASH GENE

Symbol

MAT2A

contributors: mct - updated : 27-01-2015

HGNC name	methionine adenosyltransferase II, alpha
HGNC id	6904

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart valve       Homo sapiens Digestive mouth tongue     highly Lymphoid/Immune thymus       highly Nervous brain         Reproductive male system prostate       Respiratory respiratory tract trachea     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular smooth vessel     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver, brain, testis, kidney, lymphocytes

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to C.elegans C06e7.1

Homologene

FAMILY

ADOMET synthetase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	catalyzes the production of S-adenosylmethionine from methionine and ATP, which plays a pivotal role in the methylation of neurotransmitters, DNA, proteins, and lipids
	catalyzes the transfer of the adenosyl moiety from ATP to L-methionine to synthesize S-adenosylmethionine (SAM)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

activated methyl cycle

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	binds 2 divalent ions per subunit, magnesium or cobalt
	binds 1 potassium ion per subunit

protein	transcription factor SP1 seems to play a decisive role in MAT2A induction, as it binds the promoter when the gene is being actively transcribed (
	serves as a transcriptional corepressor of MAF oncoprotein
	interacts with histone methyltransferase SETDB1 and inhibits PTGS2 gene expression

cell & other

REGULATION

Other	phosphorylation of MAT2A, MAT2B proteins during hepatic stellate cells (HSCs) activation stabilizes them thereby positively regulating trans-differentiation
	its enzymatic activity is regulated by an associated subunit MAT2B

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to familial thoracic aortic aneurysms and dissections (FTAAD)

Variant & Polymorphism other	MAT2A mutations are a rare cause of FTAAD

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS