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FLASH GENE
Symbol MAT2A contributors: mct - updated : 27-01-2015
HGNC name methionine adenosyltransferase II, alpha
HGNC id 6904
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartvalve    Homo sapiens
Digestivemouthtongue  highly
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratoryrespiratory tracttrachea  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularsmoothvessel   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver, brain, testis, kidney, lymphocytes
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to C.elegans C06e7.1
Homologene
FAMILY ADOMET synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • catalyzes the production of S-adenosylmethionine from methionine and ATP, which plays a pivotal role in the methylation of neurotransmitters, DNA, proteins, and lipids
  • catalyzes the transfer of the adenosyl moiety from ATP to L-methionine to synthesize S-adenosylmethionine (SAM)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    activated methyl cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • binds 2 divalent ions per subunit, magnesium or cobalt
  • binds 1 potassium ion per subunit
  • protein
  • transcription factor SP1 seems to play a decisive role in MAT2A induction, as it binds the promoter when the gene is being actively transcribed (
  • serves as a transcriptional corepressor of MAF oncoprotein
  • interacts with histone methyltransferase SETDB1 and inhibits PTGS2 gene expression
  • cell & other
    REGULATION
    Other phosphorylation of MAT2A, MAT2B proteins during hepatic stellate cells (HSCs) activation stabilizes them thereby positively regulating trans-differentiation
    its enzymatic activity is regulated by an associated subunit MAT2B
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to familial thoracic aortic aneurysms and dissections (FTAAD)
    Variant & Polymorphism other
  • MAT2A mutations are a rare cause of FTAAD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS