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FLASH GENE
Symbol UBE2O contributors: mct - updated : 09-01-2014
HGNC name ubiquitin-conjugating enzyme E2O
HGNC id 29554
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   moderately
Nervousbrain   highly
Respiratoryrespiratory tractlarynx  moderately
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a motif typical of the UBC domain
  • HOMOLOGY
    interspecies homolog to murine UBE2-230k
    Homologene
    FAMILY
  • ubiquitin-conjugating enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • ubiquitin conjugating enzyme activity
  • acting to disrupt the IL1B-induced association of TRAF6 with MYD88
  • UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis
  • UBE2O defines an atypical ubiquitin-signaling pathway that coordinates the function of BAP1 and establishes a paradigm for regulation of nuclear trafficking of chromatin-associated proteins
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    Ubl conjugation pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2O is a novel negative regulator of TRAF6-dependent NFKB signaling
  • UBE2O (E2-230K) is a novel interacting protein of SMAD6
  • potentiated BMP7 signalling in a SMAD6-dependent manner
  • UBE2O multi-monoubiquitinates the nuclear localization signal of BAP1, thereby inducing its cytoplasmic sequestration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS