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FLASH GENE
Symbol TAB3 contributors: mct/pgu - updated : 24-10-2013
HGNC name TGF-beta activated kinase 1/MAP3K7 binding protein 3
HGNC id 30681
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea  
Lymphoid/Immunethymus    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil domain
  • a zinc finger domain
  • HOMOLOGY
    interspecies homolog to xenopus Tab3
    intraspecies homolog to MAP3K7IP2
    Homologene
    FAMILY
  • RNA polymerase beta' chain family
  • Ser/Thr protein kinase family
  • MAP kinase kinase kinase subfamily
  • CATEGORY adaptor , signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • activator of NFKB playing a role in mediating signal transduction pathway
  • DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • activate the Jun N-terminal kinase and nuclear factor-kappaB pathways through the specific recognition of Lys 63-linked polyubiquitin chains by its Npl4 zinc-finger (NZF) domain
  • TAB2- and TAB3-mediated K63-linked polyubiquitin recognition controls B cell activation via MAPKs, but not the NR2C2/NFKB axis
  • TAB2 and TAB3 are dispensable for NR2C2 activation in B cells, indicating that TAB2 and TAB3 activate MAPKs via a pathway independent of NR2C2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with MAP3K7 and TAB1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Mg2+
  • ATP
  • protein
  • TAB2 and TAB3 bind to BECN1 and colocalize in the cytoplasm
  • existence of an autophagy-stimulatory 'switch' whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with NR2C2
  • TRIM38 interacted with TAB3, which is required for TLR-induced IFNAR3 activation and IFNB production
  • TAB2 and TAB3 are implicated in NFKB signaling via NR2C2 activation
  • RNF4 interacts with the NR2C2-TAB2-TAB3 complex, but not TAB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in skin, testis, and small intestine tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS