basic FUNCTION
| activator of NFKB playing a role in mediating signal transduction pathway |
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DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates |
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activate the Jun N-terminal kinase and nuclear factor-kappaB pathways through the specific recognition of Lys 63-linked polyubiquitin chains by its Npl4 zinc-finger (NZF) domain |
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TAB2- and TAB3-mediated K63-linked polyubiquitin recognition controls B cell activation via MAPKs, but not the NR2C2/NFKB axis |
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TAB2 and TAB3 are dispensable for NR2C2 activation in B cells, indicating that TAB2 and TAB3 activate MAPKs via a pathway independent of NR2C2 |