Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

MYADM

contributors: shn/mct - updated : 29-04-2015

HGNC name	myeloid-associated differentiation marker
HGNC id	7544

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Homo sapiens Nervous brain       lowly Homo sapiens Reproductive male system prostate       Respiratory lung       moderately Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol   bone marrow     lowly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Homo sapiens mRNA Cardiovascular endothelial cell Homo sapiens Endocrine islet cell (alpha,beta...) Lymphoid/Immune dendritic cell Homo sapiens mRNA

cell lineage	FDCP-mix cells, myeloid progenitor 32D, myeloid bone marrow, macrophage P388, macrophage J774 (
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	eight putative transmembrane segments
	one MARVEL domain

HOMOLOGY

interspecies	ortholog to Myadm, Mus musculus
	ortholog to Myadm, Rattusz norvegicus

Homologene

FAMILY

MAL family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular

basic FUNCTION	associated with the differentiation of hematopoietic cells or leukemia cells
	involved in the myeloid differentiation process, indicating that MYADM may be one useful membrane marker to monitor stem cell differentiation or myeloid leukemia differentiation
	important for the organization of membrane domains crucial for appropriate targeting of Rac1 and hence for lamellipodium extension and cell motility
	in epithelial cells, the MAL family members MAL, MAL2, and MYADM regulate the function and dynamics of ordered membrane domains
	regulates the connection between the plasma membrane and the cortical cytoskeleton and so can control the endothelial inflammatory response

CELLULAR PROCESS	cell life, differentiation
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

all-trans retinoic acid (ATRA)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

MYADM knockdown (KD) cells had altered membrane condensation and showed deficient incorporation of Rac1 to membrane raft fractions and exhibited reduced cell spreading and migration (