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FLASH GENE
Symbol SLC7A4 contributors: - updated : 31-08-2006
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
HGNC id 11062
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainmedulla oblongata  
 braindiencephalonhypothalamus  
Reproductivefemale systemplacenta   
 male systemtestis   
Respiratorylung    
Skin/Tegumentskin    
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 13 transmembrane-spanning domains,
  • 5 potential N-glycosylation sites,
  • two putative protein kinase C phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY solute carrier family 7,cationic amino-acid
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION high affinity sodium independent, transporter of cationic aminoacids, but not sufficient to mediate alone in the plasma membrane the amino-acid transport
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in velo-cardio-facial syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS