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FLASH GENE

Symbol

ADIPOR2

contributors: mct - updated : 25-02-2011

HGNC name	adiponectin receptor 2
HGNC id	24041

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       predominantly Homo sapiens Endocrine adrenal gland       highly Lymphoid/Immune lymph node       highly Nervous brain diencephalon hypothalamus   highly Reproductive female system uterus cervix   highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Homo sapiens Muscular myocyte Homo sapiens Reproductive granulosa cell Homo sapiens

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane domains that are different from classical G-protein-coupled receptors in structure and function
	a non-conserved region (AAs 1–81) restricts its cell-surface expression

mono polymer

homomer , heteromer

HOMOLOGY

interspecies

ortholog to murine Adipor2

Homologene

FAMILY

ADIPOR family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	majority of cell-surface ADIPOR2 may be present in the form of hetero-dimers, which are likely to have unique characteristics when compared with ADIPOR1 or ADIPOR2 homo-dimers, respectively

basic FUNCTION	enhancing the binding of both globular and full-length adiponectin
	major adiponectin receptors, which mediate the major, if not the entire, part of adiponectin binding and adiponectin actions
	having a functional role in bone homeostasis
	may provide an important signal linking fat and body weight to bone density
	potential role in the regulation of alcohol intake
	transcriptionally regulated by ER stress-inducible ATF3 in hepatocyte cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

repressed by

ATF3 (represses adiponectin expression in adipocytes and ADIPOR2 in hepatocytes)

Other

modulated by PPAR and LXR ligands

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in atherosclerotic lesions constitutional     --low   in obesity playing causal roles, at least in part, in the development of insulin resistance and diabetes

Susceptibility

to atherosclerosis

Variant & Polymorphism other	variants of ADIPOR2 could be a determinant for atherosclerosis independent of insulin resistance status, possibly by affecting ADIPOR2 protein levels

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS