protein
| with TRPS1(suppression of transcriptional repression activity of TRPS1) |
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binding with BMF and BCL2L11 |
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RASGRP3-interacting protein (represents a novel anchoring protein for RASGRP3 that may regulate subcellular localization of the exchange factor and, as such, may participate in the signaling mediated by diacylglycerol through RASGRP3) |
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also interacts with proteins that are not clearly connected with dynein or microtubule-based transport, including some with roles in apoptosis, viral pathogenesis, enzyme regulation, and kidney developmen |
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binds CHUK in a redox-dependent manner and thereby prevents its phosphorylation by IKK (TXNDC17 contributes to this inhibitory activity by maintaining DYNLL1 in a reduced state) |
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interacting partner of GNB2L1 (GNB2L1 formed a complex with DYNLL1 and BCL2L11, in the presence of apoptotic agents) |
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cooperate with PAK1 in malignant transformation of breast cancer cells (facilitates nuclear import of PAK1, function indispensable during vertebrate development) |
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DYNLL1 was identified as a new target of disulfide reductase activity of TXNDC17, and DYNLL1 was shown to bind IkappaBalpha in a redox-dependent manner, thereby preventing its phosphorylation by IKBKB |
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regulates syntaphilin-mediated mitochondrial docking in axons |
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POLR2M is a DYNLL1 binding partner |
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NEK9 binds to DYNLL/LC8, a highly conserved protein originally described as a component of the dynein complex (binding interferes with the interaction of NEK9 with its downstream partner NEK6 as well as with NEK6 activation, thus controlling both processes) |
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ATMIN is a DYNLL1-binding partner (DYNLL1 binds to multiple SQ/TQ motifs present in the C-terminal domain of ATMIN) |
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bind to proteins with KXTQT motifs |
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key role of ATMIN in regulating the survival of developing B cells by activating DYNLL1 expression, which may then modulate BCL2L11-dependent apoptosis |
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DYNLL1 interacted with a spindle-microtubule-associated adaptor formed by FAM83D and HMMR via TQT motifs in FAM83D) |
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binding to NEK9 was regulated by NEK9 autophosphorylation on Ser(944), a AA immediately located N-terminal to the DYNLL1 conserved (K/R)xTQT binding motif |
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WDR34 is a direct interaction partner of the cytoplasmic dynein-1 light chain DYNLL1 |
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ATMIN primarily promotes ciliogenesis by regulating DYNLL1 expression |
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