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FLASH GENE
Symbol DSG4 contributors: mct/npt - updated : 07-07-2008
HGNC name desmoglein 4
HGNC id 21307
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemprostate   
 male systemtestis   
Skin/Tegumentskin appendageshairfollicle  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningepidermisstratum spinosum 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cadherin domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Dsg4
    homolog to rattus dsg4
    Homologene
    FAMILY
  • cadherin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in homophilic cell adhesion
  • key mediator of keratinocyte cell-adhesion in the hair follicle
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+ ion binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LAH1
    Susceptibility to pemphigus vulgaris
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS