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FLASH GENE
Symbol AK7 contributors: mct - updated : 25-05-2021
HGNC name adenylate kinase 7
HGNC id 20091
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • adenylate kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    text cytosolic localization
    basic FUNCTION
  • mediates the reaction 2ADP <--> ATP + AMP, providing energy for the beating of cilia
  • both AK7 and AK8 showed highest affinity for AMP with ATP as the phosphate donor, and are more efficient in AMP phosphorylation as compared with the major cytosolic isoform AK1
  • AK7 is neuroprotective in models of Parkinson's disease
  • AK7 may have potential therapeutic significance in the intervention of noise-induced hearing loss (NIHL)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • selective Sirtuin 2 inhibitor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF27 , ICS46
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    substantially downregulated in Ovarian cancer (OC) than that in normal ovarian tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • downregulated levels of AK7 could serve as an independent prognostic indicator for the overall survival in ovarian cancer
  • Therapy target
    ANIMAL & CELL MODELS