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FLASH GENE
Symbol INS contributors: mct/npt/shn - updated : 16-10-2010
HGNC name insulin
HGNC id 6081
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
IMPRINTING maternally
text paternally expressed
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a B-chain
  • a connecting C-peptide
  • an A-chain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ins2
    ortholog to ins, Danio rerio
    ortholog to INS, Pan troglodytes
    Homologene
    FAMILY
  • insulin family
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • key protein hormone that regulates blood glucose levels and, thus, has widespread impact on lipid and protein metabolism (Jirácek 2010)
  • increasing cell permeability to monosaccharides, amino-acids, fatty acids
  • regulating the activity of ERK5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • two peptides A and B covalently linked via two disulfide bounds
  • INTERACTION
    DNA
  • SYT8 gene (
  • RNA
    small molecule
    protein
  • granuphilin (
  • leptin (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MODY10 , PNDM4
    Susceptibility to childhood obesity
    Variant & Polymorphism repeat VNTR increasing the risk of childhood obesity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS