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FLASH GENE
Symbol CADM3 contributors: mct - updated : 15-12-2010
HGNC name cell adhesion molecule 3
HGNC id 17601
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine    Homo sapiens
 intestinesmall intestine    Homo sapiens
Nervousbrain   predominantly Homo sapiens
 brainhindbraincerebellum highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
Nervousperipherous    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, fetal brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three immunoglobulin-like domains
  • a single transmembrane domain
  • a short cytosolic tail with a protein 4.1 interaction sequence and a PDZ type II motif
  • single N-glycosylation site at N290KS which influences its adhesion activity
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Igsf4b
    intraspecies homolog to TSLC1
    Homologene
    FAMILY
  • Ca-independent immunoglobulin superfamily of cell adhesion molecules
  • nectin-like family
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • functioning as adhesion molecule
  • playing an important role for mediating axon-glia contact during myelination in peripheral nerves
  • could play an important role in cell-cell interaction as well as in tumor suppression
  • mediate critical interactions between Schwann cells and axons during myelination
  • has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity, and plays an important role in the formation of synapses, axon bundles, and myelinated axons
  • neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca(2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons
  • may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
  • with CADM4, suppress the growth and tumorigenic ability of colon cancer cells
  • plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    G-protein coupled receptor protein signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding partner for CADM4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in glioma and prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS