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Symbol UBE2D2 contributors: mct/npt - updated : 02-10-2018
HGNC name ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
HGNC id 12475
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • functional E2 protein which, together with FBXW2, regulates GCM1 stability in the placenta (Chiang 2008)
  • physiological ubiquitin-conjugating enzymes E2s for MDM2, which make a significant contribution to the maintenance of low levels of TP53 and MDM2 in unstressed cells (Saville 2004)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS