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FLASH GENE
Symbol RELB contributors: mct - updated : 12-09-2017
HGNC name v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)
HGNC id 9956
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a bipartite arginine/lysine-rich NLS mediating the binding of RElB to importin alpha5 and alpha6 and subsequent nuclear translocation of the protein
    • conjugated sumoylated
    HOMOLOGY
    Homologene
    FAMILY
  • PPP phosphatase family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    text
  • is always present in the mitochondrial fraction
  • NFKB family members NFKB2 and RELB translocate to the nucleus in response to CO2
    • basic FUNCTION
  • can repress proinflammatory gene expression, and its expression in sepsis patient blood leukocytes may play a role in the endotoxin-tolerant phenotype
  • functionally associated with the aryl hydrocarbon receptor (AHR) and mediates transcription of chemokines such as IL8
  • NF-kappaB subunit downstream of MAP3K14 responsible for osteoclast differentiation
  • playing a role in the crosstalk between non-hematopoietic stromal cells and leukemic cells
  • contributes to tumorigenicity of prostate cancer
  • responsible for the lipopolysaccharide-mediated attachment and may play an important role in the progression of some cancers
  • inhibits cell proliferation and tumor growth in a TP53-dependent manner
  • function for RELB as an important regulator of the mammalian circadian system in fibroblasts
  • RELB controls dendritic cell (DC) maturation
  • negatively regulates osteoblast differentiation and bone formation
  • is a novel regulator of human pluripotent stem cells (hPSCs) proliferation, suggesting a new function for RELB, in addition to its widely accepted role as a transcription factor, the post-transcriptional modulation of IGF2 and cell-cycle gene expression
  • role of RELB on lymphocyte development , and in the absence of RELB, B cells development is arrested, resulting in poor production of immunoglobulins and specific antibodies
  • critical role for the combined activity of the RELB and NFKB2 subunits in B cell homeostasis that cannot be compensated for by the canonical NFKB pathway under physiological conditions
  • functioned as an oncogene in prostate cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RELB/NFKB2 signaling positively and intrinsically regulates hematopoietic stem/progenitor cell (HSPC) self-renewal and maintains stromal/osteoblastic niches
    • a component
  • RELB/NFKB1 regulates CCL19 production, but fails to promote dendritic cells maturation
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARNT is a TNFRSF8-interacting protein that modulated the activity of the RELB subunit of the transcription factor nuclear factor kappaB (NF-kappaB)
  • interacting with DPF2 (functions as an efficient adaptor protein between the SWI/SNF complex and RELB and plays important roles in noncanonical NF-kappaB transcriptional activation and its associated oncogenic activity)
  • GSK3B is a crucial regulator of RELB degradation, stressing the relevant linkage between the NFKB system and GSK3B
  • CHUK and IKBKB are RELB interacting partners whose activation by TNF promotes RELB phosphorylation at serine 472
  • SIRT1-RELB induction of mitochondrial biogenesis included increases in mitochondrial mass, mitochondrial-to-nuclear DNA ratios, and both nuclear and mitochondrial encoded proteins
  • TNFSF13B signals coordinate both RELB and REL activities to ensure survival during peripheral B-cell maturation
  • RELB is necessary for the effective production of downstream TNFRSF11A(+) mTEC (medullary Thymic epithelial cells) progenitors
  • NKRF is a novel RELB-response gene, and Neutrophil elastase (NE) is a stimulator of the non-canonical RELB/NFKB1 pathway in airway smooth muscle cells
    • cell & other
    REGULATION
    Other SUMOylation of RELB might be one of these post-translational modifications rendering the function of the NFKB transcription factor RELB
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD53
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    developing a RELB-targeted therapeutic intervention, is valuable in treating advanced, metastatic prostate cancer
    ANIMAL & CELL MODELS
  • RelB(-/-) mice develop age-related increased trabecular bone mass associated with increased bone formation