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FLASH GENE

Symbol

ANP32B

contributors: mct - updated : 23-02-2015

HGNC name	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
HGNC id	16677

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart       highly Digestive liver         Endocrine pancreas       highly Nervous brain         Reproductive male system prostate     highly Respiratory lung       highly Skin/Tegument skin appendages         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial barrier/lining

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	testis carcinoma and muscle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N terminal leucine rich repeats (LRR), that possesses histone chaperone activity and forms a curved structure with a parallel beta-sheet on the concave side and mostly helical elements on the convex side
	C terminal acidic clusters, and variable anionic region, functioning as an inhibitor of histone acetylation

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Anp32b
	homolog to Drosophila CG3961
	homolog to C.elegans Y65B4BL.5

Homologene

FAMILY	acidic (leucine-rich) nuclear phosphoprotein 32 family
	LRR subfamily

CATEGORY

chaperone/stress , protooncogene , receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus
text	translocated partially to the nucleoli after heat shock
	localize in the nucleus

basic FUNCTION	involved in antigen-mediated cellular responses, leukemogenesis and differentiation
	participating in signal transduction directing nucleolar activities by regulating ribosomal RNA biosynthesis
	shuttle phosphoprotein required for ELAVL1-mediated nucleocytoplasmic translocation of the CD83 mRNA by acting as an adaptor that links ELAVL1 and XPO1
	novel substrate for caspase-3 and acts as a negative regulator for apoptosis
	with other ANP32 proteins have been implicated in a broad array of physiological processes, including cell differentiation, apoptotic cell death, and cell proliferation
	potential role for ANP32B in vascular development
	inhibitory role of ANP32B against leukemic cell differentiation
	potential role of ANP32B in regulating retinoic acid receptor signaling
	ANP32A, ANP32B, ANP32E represent an important node of physiological regulation by virtue of their diverse biochemical activities

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to RNA polymerase 1
	KLF5 interacts with the novel histone chaperone acidic nuclear phosphoprotein 32B (ANP32B), leading to transcriptional repression of a KLF5-downstream gene
	histone chaperone that specifically bound to the transcription factor KLF5, leading to transcriptional repression of KLF5-downstream genes through inhibition of promoter histone acetylation
	direct substrate of caspase-3 and it is primarily cleaved at the sequence of Ala-Glu-Val-Asp, after Asp-163
	interaction of ANP32B with the core histones H3-H4 occurs on its concave side, and both the acidic and hydrophobic residues that compose the concave surface are critical for histone binding
	direct substrate for CASP3 and acted as a negative regulator for leukemic cell apoptosis
	might exert this role through inhibiting the all-trans retinoic acid (ATRA)dependent transcriptional activity of retinoic acid receptor (RARA)
	TNFRSF13B binds the cytokines TNFSF13B and ANP32B
	inhibit the expression of the anti&
	8209;apoptotic protein BCL2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   correlates with shortened patient survival

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	ANP32B mRNA expression in human breast cancers may serve as a prognostic marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   may serve as a potential therapeutic target for leukemia treatment

ANIMAL & CELL MODELS

surviving Anp32b-deficient mice showed reduced viability due to variable defects in various organ systems