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FLASH GENE
Symbol ATP6V1A contributors: mct/npt - updated : 01-07-2014
HGNC name ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
HGNC id 851
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus  
Olfactory (smell)olfactory bulb     Mus musculus
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Olfactoryepithelial cell Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text adrenal gland
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , trimer , complex
HOMOLOGY
Homologene
FAMILY
  • ATPase alpha/beta chains family
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • ATP synthase H+ transporting, catalytic subunit of the peripheral V-1 complex of the vascular proton pump
  • in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles (Pietrement 2006)
  • may be involved in proton secretion in the olfactory epithelial (OE) cells and, as such, may be important for the pH homeostasis of the neuroepithelial mucous layer and/or for signal transduction in CO(2) detection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the heteromultimeric complex composed of a peripheral catalytic V1 complex attached toan integral V0 membrane pore complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physical interaction between aldolase and vacuolar ATP6V1A is essential for the assembly and activity of the proton pump
  • RAB11B is a crucial regulator and RAB11FIP5 as mediator of acidosis-induced ATP6V1A traffic in duct cells of submandibular gland
  • interaction between WFS1 and ATP6V1A (proton pump) and this interaction may be important both for pump assembly in the ER and for granular acidification
  • WFS1 may be necessary for the stability of ATP6V1A and ATP1B1, but does not protect ATP6V1A and ATP1B1 from proteasome-mediated degradation
  • cell & other
    REGULATION
    Phosphorylated by by the metabolic sensor AMP-activated protein kinase (AMPK) in kidney cells
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCL4A
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS