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FLASH GENE
Symbol DLL3 contributors: mct/pgu - updated : 27-09-2011
HGNC name delta-like 3 (Drosophila)
HGNC id 2909
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid    
Nervousbrain     Homo sapiens
Respiratorylung    
Skeletonaxial skeleton    
Skin/Tegumentskin    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text
  • in presomitic mesoderm
  • expressed broadly in the developing nervous system as neural progenitor cells initiate differentiation
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six EGF-like domains
  • one DSL domain
  • one transmembrane domain
  • HOMOLOGY
    Homologene
    FAMILY
  • delta protein ligand family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • predominantly in the Golgi apparatus
  • co-localization of DLL3 and NOTCH1 occurs only in cytoplasmic vesicles that are likely to be late endosomes and lysosomes
  • basic FUNCTION
  • playing a role in the formation of somite boundaries during segmentation of the paraxial mesoderm
  • may be required to divert neurons along a specific differentiation pathway
  • having potential physiological functions in the Golgi network
  • required for the correct spatio-temporal activation of NOTCH1 during somitogenesis
  • ligand of Notch, inhibiting receptor signaling, cannot activate signaling
  • may alter the trafficking of full-length NOTCH1 by sequestering it to late endosome/lysosomes, thereby preventing its S1 processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NOTCH receptor ligand
  • interaction with HUWE1 (ubiquitin ligase HUWE1 operates upstream of the MYCN-DLL3-NOTCH1 pathway to control neural stem cell activity and promote neurogenesis)
  • interacts with the unprocessed full-length form of NOTCH1 (NOTCH1 inhibition by DLL3 implicated in abnormal vertebral segmentation in spondylocostal dysostosis)
  • cell & other
    REGULATION
    Other a complex interplay of E-box binding proteins spatially and temporally regulate DLL3 levels during neural tube development
    ASSOCIATED DISORDERS
    corresponding disease(s) SCDO1
    Susceptibility to vertebral malformations
    Variant & Polymorphism other "G" to "A" missense mutation changing glycine to arginine at codon 269, may be associated to vertebral malformations
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • targeted deletion of Dll3 in the mouse causes a developmental defect in somite segmentation, and consequently vertebral formation is severely disrupted, closely resembling human SCD