Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KIF1B contributors: mct/pgu - updated : 13-04-2017
HGNC name kinesin family member 1B
HGNC id 16636
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain   highly
 spinal cord   highly
Reproductivefemale systemovary   
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines favorable neuroblastoma cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain, kidney, skeletal muscle, pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one kinesin motor domain
  • one FHA domain
  • one pleckstrin homology (PH) domain at C terminus, lacking a motor domain
  • HOMOLOGY
    interspecies homolog to murine Kf1b
    intraspecies homolog to ATSV (KIF1A)
    Homologene
    FAMILY
  • kinesin-like protein family
  • UNC104 subfamily
  • Kinesin-3 family
  • CATEGORY motor/contractile , tumor suppressor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • involved in transport of synaptic vesicle precursors, in the anterograde transport of mitochondria
  • kinesin superfamily member involved in the transport of organelles and vesicles
  • motor proteins implicated in anterograde transport of mitochondria and synaptic vesicle precursors
  • STARD13 and KIF1B are thus central components of a signalling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text neuronal differentiation and survival
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to the specific region of KIF1B (813-916 aa), but not to other kinesin family members
  • XAF1 is likely a downstream target of KIF1B beta
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2A1
    related resource Mutation Database of Inherited Peripheral Neuropathies
    KinMutBase: A registry of disease causing mutations in tyrosine kinase domains
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in favorable subset of primary neuroblastoma
    tumoral     --low  
    in unfavorable subset of primary neuroblastoma
    Susceptibility
  • to multiple sclerosis
  • to hepatitis B virus (HBV)-related hepatocellular carcinoma
  • Variant & Polymorphism SNP
  • variant rs10492972 (SNP located in intron 5) associated to multiple sclerosis
  • intronic SNP (rs17401966) highly associated with HBV-related HCC (
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS