multiple alternatively spliced transcripts co-expressed in the same cell types and induced upon the same signals of activation (PMID: 20843815 )
identification
nb exons
type
bp
product
Protein
kDa
AA
specific expression
Year
Pubmed
5
splicing
5167
-
191
-
2010
20843815
LLT1 variant 1
bind to KLRB1
5
splicing
5249
-
194
-
2010
20843815
remained in the endoplasmic reticulum, forming homodimers or heterodimers with LLT1
variant 2
possess C-type lectin-like domains between amino acids 75 and 185 and between amino acids 75–192, respectively
do not bind to KLRB1
4
splicing
5176
-
132
-
2010
20843815
remained in the endoplasmic reticulum, forming homodimers or heterodimers with LLT1
composed of exons 1, 2, 3, and 5
variant 4
has lost C-type lectin-like domains
do not bind to KLRB1
4
splicing
5146
-
154
-
2010
20843815
variant 5
3
splicing
5042
-
51
-
2010
20843815
EXPRESSION
Type
expressed in
(based on citations)
organ(s)
tissue
System
Tissue
Tissue level 1
Tissue level 2
Level
Pubmed
Species
Stage
Rna symbol
Blood / Hematopoietic
Lymphoid
cells
System
Cell
Pubmed
Species
Stage
Rna symbol
Lymphoid/Immune
B cell
Lymphoid/Immune
dendritic cell
Homo sapiens
Lymphoid/Immune
natural killer
Homo sapiens
Lymphoid/Immune
T cell
Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
transmembrane domain near the N terminus
an extracellular domain similar to the carbohydrate recognition domain of C type lectin but without an intracellular ITIM, immunoreceptor, tyrosine based inhibitory motif
CLEC2D-stimulated IFN-gamma production in NK cells may involve post-transcriptional or translational events (
role for CLEC2D/KLRB1 in modulating immune responses to pathogens
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
signal transduction
a component
INTERACTION
DNA
RNA
small molecule
protein
ligand for the NK cell inhibitory receptor, NKR-P1A (KLRB1)
ligand of KLRB1, found to be expressed on Toll-like receptor (TLR)-activated plasmacytoid and monocyte-derived dendritic cells (DC) and on activated B cells
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
to reduction of bone mineral density in postmenopausal women
Variant & Polymorphism
other
women with a lysine (GG genotype) at position 19 displayed lower BMD at femoral neck and at lumbar spine sites than women having an asparagine residue